Bespoke DNA, RNA and modified oligonucleotide synthesis
Therapeutic ASO chemistry, dual-labelled diagnostic probes, NGS oligos, novel chemistries.
Find the right pathway
For researchers
Standard and modified oligos for academic and industrial benchwork.
For diagnostics
Probe chemistry, qPCR primers and controls for diagnostic assays, with batch traceability.
For therapeutic discovery
ASO chemistry, complex modifications and scale-up for in vivo studies.
For complex projects
Consultation with experts in the field on unusual chemistries and novel modifications.
Therapeutic oligonucleotides
Antisense, splice-switching, siRNA, miRNA, CRISPR guide RNAs and aptamers, with the backbone, sugar and conjugation chemistry to match, from discovery quantities to larger batches for in vivo work.
Diagnostic oligonucleotides
Dual-labelled probes and primers for diagnostic assays, HPLC purified, verified by UPLC-MS, with full batch traceability.
Next-generation sequencing (NGS)
High-specification oligonucleotides for sequencing platforms, made to the exacting standards that NGS applications demand.
Whether you are a platform developer or a company whose technology relies on reliable, well-characterised oligonucleotides, tell us your requirements in detail.
Applications include:
- Sequencing primers and hybridisation probes
- Custom sequences for instrumentation development
Specialist and exploratory synthesis
Some work involves sequences that are novel: unusual chemistries, bespoke probe designs, or early-stage exploratory synthesis where the application is still being defined.
If you are working at the frontier of nucleic acid research and need a synthesis partner, tell us about the project.
Applications include:
- Bespoke modified sequences and novel chemistries
- Custom probe and sensor designs
- Early-stage and exploratory synthesis
- Research applications that fall outside standard categories
Novel chemistry development
If you need to go beyond what is currently available, tell us what you are trying to make. We offer collaborative chemistry development partnerships: working closely with your team, we explore new modification chemistries and translate research-stage chemistry into reliable, reproducible synthesis workflows. This is where the expertise of our founding team matters most. If you have a chemistry challenge, we would like to hear about it.
Oligonucleotide analysis
Every synthesis order includes analytical characterisation, identity confirmation and purity assessment, and the same analysis is available as a stand-alone service.
If your project needs a customer-defined analytical method or a tailored level of analysis, tell us the requirement.
Services include:
- UPLC-MS analysis
- UPLC purity analysis
- Characterisation of customer-supplied oligonucleotides
- Duplex and triplex melting analysis
Not sure where to start?
Projects range from complex oligonucleotide modifications and challenging synthesis requirements to time-sensitive work and early-stage exploratory research. Whether you have a well-defined target or are still exploring the best approach, get in touch.