Technical articles, methods, presentations and long-form writing from the Assemblon team.
How the molecular structure of DNA and RNA governs their chemical properties, stability, recognition and biological function, from canonical base pairing to modified nucleobases, sugars, backbones and higher-order structures. With the full slide deck.
A streamlined approach to oligonucleotide functionalisation through direct on-support phosphitylation of the growing chain, giving access to diverse terminal and internal modifications beyond current phosphoramidite strategies.
Phosphothiotriester (PTTE) and phosphate-triester (PTE) backbone chemistry as a synthetically accessible, modular alternative to the conventional phosphorothioate backbone used in most approved oligonucleotide therapeutics.
Assemblon is now accepting orders for custom oligonucleotide synthesis across therapeutics, diagnostics, R&D and many other applications, with a consultative approach that puts science first.